Different milling instruments and conditions were compared to investigate the effect of different milling protocols on cannabinoid recovery. It was found that a Fritsch Pulverisette 11 with a single use container shows comparable to higher recoveries of cannabinoids, while having the added benefits of protecting against cross contamination and reducing cleaning time and costs.
In this article, Markus Roggen demonstrates a new method for recapturing terpenes lost during the cannabis extraction process. Terpenes provide cannabis with distinctive aromas and flavors that are often desired by the consumer. During the cannabis drying and decarboxylation stages, up to 30% of terpenes are lost along with the water phase from the product…
In many ways, major Cannabis companies are like pharmaceutical companies. They produce and sell products used for medicinal purposes, and their main pages have statements on how science is the most important thing in their work. We looked at 10 major pharmaceutical companies, and 10 major cannabis companies, and compared what positions they had for scientists, and their R&D spending. Unlike pharmaceutical companies, cannabis companies rarely have any scientists in the executive suites. Further, R&D spending from most of the cannabis companies we looked at was below 5% of their annual income (less than many agricultural companies), indicating these companies are not putting their money where their mouth is.
Following the release of footage showing a patient in a study conducted by MAPS being inappropriately touched by two therapists, all Health Canada-approved MDMA trials have been halted for review. Multiple other participants have come forward with negative experiences, practitioners have pointed out flaws in the therapeutic techniques being used, and scientists have pointed out mishandlings of data representation in publications put out by research groups. As critical supporters of psychedelic research, we point out ways we can improve to ensure it is being done in the most ethical way possible and to ensure the industry survives as more than just another fad.
Compass Pathways was granted a patent for what they claim to be a newly discovered crystalline form of psilocybin. This patent would allow Compass to exclude others from benefitting from the use of that crystalline form. That patent was challenged in court due to ambiguous scientific jargon and, more critically, because Polymorph A is not a new polymorph at all. We explain what crystal polymorphs are, why finding new polymorphs is significant, and why scientists are able to claim this new crystal structure not new at all.
In this op-ed, Dr. Roggen et al. propose a system for websites like Leafly that would allow its users to share revenue from their content and personal data, enabling a higher sense of trust, credibility and ultimately more value for every stakeholder involved. Using NFTs, they suggest consumers in the cannabis industry could generate a product and benefit from it too
The poisonous chemical components of molds found in crops like cannabis, wheat, rice, and corn are called mycotoxins. Mycotoxins are a huge problem in cannabis, but they are difficult to detect. Here we explain some of the analytical challenges of mycotoxin detection in cannabis and what is required moving forward.
In this written Q&A, Dr. Roggen discusses the importance of understanding psilocybin’s chemistry, getting licensed to research psilocybin by Health Canada, and the similarities and differences of cannabis vs. psilocybin research. The interview also covers psilocybin’s growing prevalence and popularity, the unknowns that researchers hope to understand, and more!
The 2018 Farm bill legalized any cannabis and related products with less than 0.3% delta 9 THC, leaving a loophole for products with the intoxicating delta 8 THC, which is both naturally occurring and can be made from CBD. This has left those in the market wondering if delta 8 products will be a threat to those in the delta 9 market, or if it will be another opportunity.
Unadulterated cannabis concentrates can contain unknown substances depending on how they were produced. One compound that recently appeared is known as Delta-10-THC, an almost entirely unexplored form of THC. The cannabinoid has only been discovered after cannabis was highly processed, although it is touted as plant-derived by some companies. So, is delta-10-THC natural or synthetic?